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Schematic of the experiments used to determine the effect of localization on DNA file concentration distributions after PCR amplification in bulk or within either water-in-oil emulsion droplets or proteinosomes in water. Multiplex PCR was used to amplify twenty-five 1 MB DNA-encoded files, totalling 25 MB. Purified reaction mixtures were subsequently sequenced using Illumina sequencing and aligned to reference sequences to determine per-file coverage (Methods). NGS, next-generation sequencing.

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