Protein Structure from Scientific Research
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Superimposition of views from crystal structures of M pro with GM4 and nirmatrelvir (Protein Data Bank 7VH8 (ref. 60 )). GM4 non-covalently interacts at the active site, while the nitrile of nirmatrelvir reacts with C145. Note the similar locations of the nirmatrelvir nitrile-derived N and the H3 GM4 carbonyl O.
#Protein Structure#Chemical Structure#M Pro#GM4#Nirmatrelvir#Crystal Structure#Active Site#Nitrile#Carbonyl
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