Bar Plot from Scientific Research

Oncoprint of genes with somatic mutations that are associated with low ICR score as determined by fitting of binomial linear regression models. Binomial linear models were generated for non-hypermutated and hypermutated subgroups separately. All genes with P value < 0.05 as predictor variable in the regression model are displayed. Orange triangle marks genes that were associated with lower ICR score in non-hypermutated samples, whereas the blue triangle highlights genes associated with low ICR in hypermutated samples. Significance of the association is indicated on the left of the plot. Box-plot of ICR score by tumor histology (mucinous versus all other histological classifications) in hypermutated samples, mutated in either of the homologous recombination (HR) repair genes ( BRCA1 , BRCA2 and FANCA ) are indicated by the color of the dots. P value is calculated using unpaired, two-sided Student’s t -test. AC, adenocarcinoma; NOS, not otherwise specified; MUT, mutant; WT, wild-type.

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