C-terminal RELN and APOE staining of the cases with RELN-COLBOS , APOECh , familial AD and sporadic AD in the ERC and CA1. The case with RELN-COLBOS shows a stronger background signal in both structures with lower intraneuronal signal for C-terminal RELN in the ERC. Similarly, the case with APOECh shows lower intraneuronal signal in ERC with the C-terminal RELN antibody and very low intraneuronal signal in both structures with the APOE antibody (magnified right). Finally, APOE staining shows noticeable plaque- and tangle-like signals in cases with familial and sporadic AD in both structures, the ERC and CA1. Scale bars, 100 m and 25 m in the magnified panel.
