Microscopy from Scientific Research

Representative immunohistochemistry (IHC) images from the HIC of WT/WT, WT/ RELN -H3448R, hTau tg/WT and hTau tg/ RELN -H3448R mice stained with hyperphosphorylated Tau (pTau) T205 antibody. hTau tg/WT mice showed neurofibrillary tangles and neuropil threads in the first region of the hippocampal circuit (CA1) and dentate gyrus, while hTau tg/ RELN -H3448R showed Tau pathology to a lesser degree (soma of an affected neuron depicted with a dotted line). Bar scale, 100 μm.

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