Representative PiB PET amyloid and FTP Tau PET imaging of the male case with RELN-COLBOS (left) compared to a PSEN1- E280A mutation carrier with MCI at a typical age (right). For both measurements, specific binding of the tracer is represented using a color-coded scale with blue being the lowest (DVR or SUVR = 0.8) and red being the highest (DVR or SUVR = 2.00) degree of binding. Right, representative FDG PET precuneus cerebral metabolic rate for glucose (CMRgI) of the male case with RELN-COLBOS (left) compared to a PSEN1 -E280A carrier with MCI at a typical age (right). Binding affinity of the dye is represented using a color-coded scale with blue being the lowest (SUVR = 0.5) and red being the highest (SUVR = 2.1) degree of binding. PHF, paired helical filament.
