Dot plot analysis of the imaging measurements shown in a for amyloid and Tau burden, glucose metabolism and hippocampal volume. Brain imaging measurements of the male case with RELN-COLBOS (red dot) compared to the previously published APOECh homozygote female (blue dot), unimpaired PSEN1 -E280A carriers (gray dots, n = 18 for the glucose metabolism panel, n = 13 for all other panels) and younger carriers of the MCI PSEN1 -E280A mutation (black dots, n = 7 for the Tau burden plot, n = 8 for the amyloid burden and hippocampal volume plots, n = 11 for glucose metabolism) 2 . Some previously published data points are included in the figures because they are the only available data for comparison 2 . Data are expressed as individual values with the mean s.e.m.
