Scatter Plot from Scientific Research

The effects of protein-truncating, missense (stratified by MPC) and synonymous variant burden in the exome sequencing study identified DD 13 and ASD genes 12 on EDU, RT and VNR. Unrelated UKB EUR samples were included in this analysis ( n = 318,844 for EDU, n = 319,536 for RT and n = 128,812 for VNR). Missense variants were classified according to deleteriousness (MPC) into three tiers: tier 1, MPC > 3; tier 2, 3 >= MPC > 2; tier 3 includes all missense variants not in tier 1 or 2. Data are presented as effect size estimates ( beta ) with 95% CIs.

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