Bubble Plot from Scientific Research

Comparison between gene-based associations for DD, EDU and VNR (PTV de novo mutation enrichment tests (simulation-based test) and DeNovoWEST (simulation-based test) for DD; rare PTV burden association tests (two-sided t -test) for EDU and VNR). Each dot represents a gene that was identified for DD in Kaplanis et al. 13 or for EDU or VNR in the current exome analysis. The dots are color-coded according to the phenotypes (DD, ASD, EDU and VNR) that the gene is significantly associated with exome-wide. The size and shade of the dots represent the pLI for the gene. EDU and VNR genes are labeled with gene names.

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