Manhattan Plot from Scientific Research

Exome-wide, gene-based PTV burden association for RT (related UKB EUR sample n = 394,600). The -log 10 P values (two-sided t -test) for each gene were plotted against the genomic position (Manhattan plot). The orange dashed line indicates the Bonferroni-corrected exome-wide significance level per phenotype ( P < 0.05/15,798 = 3.16 × 10 -6 for RT).

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