Clustered from Scientific Research

Power to detect a rare causal variant (MAF = 0.025%) in simulations of a polygenic phenotype. We compare ARG-MLMA of ground-truth ARGs and ARG-Needle-inferred ARGs with MLMA of imputed and SNP array variants as we vary the effect size (100 independent simulations of h 2 = 0.8, = -0.25, N = 20,000 haploid samples and 22 chromosomes of 5 Mb each; Methods ).

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