Scatter Plot from Scientific Research

Representation of the SCAD TWAS z score for each prioritized gene in GWAS loci. The point shape indicates the tissue used in the TWAS association. The point color distinguishes genes located at different loci. The absence of a symbol indicates that the gene did not show significant heritability based on the eQTL data in the corresponding tissue. TWAS P values were calculated by two-tailed z test against a null distribution calculated by permutation for each gene or tissue 44 . Higher opacity is used to identify significant associations (Bonferroni adjusted P < 0.05), corresponding to a z score of >4.8 or <-4.8 (dashed gray lines).

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