Scatter Plot from Scientific Research

Schematic for integrating accessible chromatin, transcriptome and protein modalities into spatially resolved and segmented nuclei. High-resolution clusters were generated from scSeq data (RNA/ATAC metacells) of the closest matching timepoints to the imaging data. Label transfer was predicted based on correlation of RNA and protein features in sequenced cells and imaged nuclei, respectively. Left UMAP shows timecourse metacell embedding based on transcriptome and colored by cell type with 39-week cells highlighted. Right UMAP shows nuclei embedding based on protein features colored according to label transfer from the transcriptome space.

DOI