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Plasma LDL cholesterol in mice treated with prime editing AAV normalized to untreated mice at the same age. Data are shown as mean s.e.m. for n = 8 mice (four male and four female), * P = 0.0064 and P = 0.023, respectively. Significance was calculated using two-way repeated-measures ANOVA with Sidak multiple comparisons and is shown for the 8-week timepoint.
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