Heatmap showing the potency of 162 WT phages (horizontal axis) against 82 E. coli strains (vertical axis) based on growth kinetics. iAUC values are shown as a gradient of green. Phage genome size based on the sequencing data is shown in the top bar graph. For a selected group of phages, the cognate bacterial receptor protein was determined and shown in the bottom panel. The phage taxonomical classification based on the sequencing data is annotated in the bottom bar. The top tree shows the relationship between the phages based on their growth kinetics. The eight phages that were selected for engineering (alpha15, alpha17, alpha20, alpha31, alpha33, alpha46, alpha48 and alpha51) are highlighted by circles, four of those (alpha15, alpha20, alpha48 and alpha51) that form the basis of SNIPR001 are colored green.
