Cell type profiling score (as determined using Nanostring IO360) of CD8 vs Treg by outcome compared between pre- (left) and on-treatment (right) samples as indicated at the bottom of the graph. Pre-treatment = 22 ( n PR = 8, n SD = 6, n PD = 7), On-treatment=19 ( n PR = 8, n SD = 6, n PD = 5), biologically independent; two-sided MannWhitney U -test, adjusted for multiple comparisons, boxplots are shown with the boxes indicating quartiles with median at middle and the whiskers drawn at the lowest and highest points within 1.5 interquartile range of the lower and upper quartiles, respectively. Each dot represents an individual sample.
