Histopathological scoring of lung lesions ( n = 4 per infection group). Representative pathological features are reported in our previous studies 2 , 17 , 26 , 31 , 32 . In ( a – c , e ), data are presented as the average standard error of mean (SEM). In ( c ), each dot indicates the result of an individual hamster. In ( a , b ), and ( e ), statistically significant differences between BA.5 and other variants across timepoints were determined by multiple regression. In ( a ), the 0 d.p.i. data were excluded from the analyses. The familywise error rates (FWERs) calculated using the Holm method are indicated in the figures. In ( c ), the statistically significant differences between BA.5 and other variants were determined by a two-sided MannWhitney U test. In ( c , d ), each panel shows a representative result from an individual infected hamster. Scale bars, 500 m ( c ); 200 m ( d ).
