Network diagrams of metabolites in neutrophils from control, mild, or severe COVID-19 patients. A magnification of a new cluster of glycolytic and PPP metabolites in severe patients is shown in ( k ). Red dots represent elevated metabolites and blue dots depleted metabolites in neutrophils from severe COVID-19 patients compared with healthy controls. Statistical significance was assessed with two-tailed t -tests followed by multiple comparisons correction ( b – d ). In all figures, multiple comparisons correction was performed by controlling the false discovery rate at 5% using the method of Benjamini, Krieger, and Yekutieli for metabolomics analysis, or by using multiple comparisons tests as described in the methods.
