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Effect of 1938 on the catalytic activity of oncogenic mutants of PI3Ka. Data shown as n = 2 independent experiments (b, e). Data shown as the mean s.e.m., n = 6 (c, top), n = 4 (c, bottom), n = 3 (d, f, g) experiments. Kinetic values in d shown as the mean s.d. Statistical analysis performed using two-way analysis of variance (ANOVA), Tukey’s multiple comparisons test (c), Dunnett’s multiple comparisons test (g) or one-way ANOVA, Dunnett’s multiple comparisons test (f). **** P < 0.0001.
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