Illustration from Scientific Research

Schematic representation of RNF111 showing its characterized domains: the three SUMO-interacting motifs (SIM) and C-terminal RING domain. The sequence of the RING core is indicated below with the cysteines and histidines of the RING-H2 domain in bold. Mutation of the first cysteine of the RING domain is annotated in red. A schematic representation of the “cross-brace” zinc finger structure of the RING domain is shown [ 12 ].

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