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Schematic representation of Flag-tagged constructs expressing RNF111 (human) or RNF165 (rat) used in this study. The sequence alignment of the RING core is indicated below. Identical amino acids are highlighted in yellow. The RING core is 80% identical between RNF111 and RNF165. Note that the RING core sequence of RNF165 is identical in rat and human. The sequence alignment with human PIRH2, another RING-H2, is also indicated.
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