Possible pathways underlying these disease event rates. While there are many pathways to RSV death (and therefore different probabilities of dying for different treatment pathways), for simplicity only one rate of RSV mortality is required by the model. Similarly, while many healthcare utilisation pathways (clinic visits and/or hospital admissions) are possible, for simplicity all this activity is captured within a single rate of RSV hospital admissions, and two rates of RSV clinic visits (one for severe RSV and one for non-severe RSV). The model does not include a separate category for emergency room (ER) visits, and since the model will assume the same efficacy and treatment costs for all outcomes that are grouped together, country teams should clarify whether ER visits are included within the estimated rate of clinic visits or hospital admissions. Estimates of the average treatment cost per patient should also be adjusted appropriately to account for the contribution and cost of ER visits
