Scatter plot of the Z statistics of MR estimates of traits showing suggestive causal evidence with anti-VZV IgG levels using IVs outside MHC region (IV mhc , vertical axis) or all IVs (IV full , horizontal axis). The combined MR results inferred from different methods, which are suggested by different colours. The dashed lines are the 95% confidence interval (CI) of Z statistics. Dots outside the CI are statistically significant ( P < 0.05) MR results. The annotation on the bottom-left of each figure shows the Spearman correlation estimate (cor) and P -value of the correlation test. The legend on the bottom-right of each figure represents the number of the results that are statistically consistent (con) and statistically inconsistent (incon)
