Bar Plot from Scientific Research

Downsampling approach testing the sensitivity of ACT-Discover in the context of reduced effective tumour content. At simulated purity of ~ 10% (i.e. 10% PDX content), 97% of this allelic imbalance remained detectable. Even at 1% effective purity, 20% of allelic imbalance was detectable, and at 0.1% effective purity, it was still possible to detect allelic imbalance, albeit only 5%.

DOI