A working model for the regulatory roles of m6A readers CPSF30-L and ECT2/ECT3/ECT4. In the nucleus, CPSF30-L binds m6A-modified transcripts and regulates its poly(A) site choice; in the cytoplasm, m6A readers ECT2, ECT3, and ECT4 interact each other, where ECT2/ECT3/ECT4 bind m6A-modified transcripts tightly and recruit the poly(A) binding proteins through the direct interaction between ECT2 and PAB2/PAB4, thereby preventing deadenylation and stabilizing their targeted mRNA. In ABA response, ECT2/ECT3/ECT4 redundantly maintain mRNA stability of ABA response-related genes (e.g., DWA1 , DWA2 , SDIRIP1 , and CPN20 ), thereby repressing the accumulation of ABI5 and regulating ABA-mediated seed germination and post-germination growth
