Heatmap of mean peak agreement across RBPs. Only RBPs for which an enriched motif (see “ Methods ”) was found are included. The agreement is calculated as the Jaccard index of the nucleotides (nts) in the peaks, where the intersection of two sets of peaks is the number of nts covered in both sets, while the union is the number of nts covered in at least one of the two sets. The color range is capped at a similarity of 0.3 to make the clusters more easily distinguishable. The top peaks are taken according to the FDR threshold (0.1), extending by 20 nts upstream and downstream from the crosslink site. Since there are multiple replicates per RBP, the mean of pairwise Jaccard indices over all combinations of sample pairs are used here. The colors on the left indicate the relative frequency of each nucleotide type averaged over all positions of the PWM.
