Chemical Structure from Scientific Research

Reaction conditions: epoxide (0.2–0.4 mmol, 1 equiv), vitamin B12(cyanocobalamin, 1 mol %), TRIP thiol (2,4,6-triisopropylbenzenethiol, 10 mol %), Zn (3 equiv), NH4Cl (3 equiv), MeOH (0.1 mmol epoxide/mL), 427 nm LED (Kessil), 2–48 h, isolated yield. Products 2E (2 h) and 2E’ (16 h) both form by reaction of epoxide 1E.

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