Top scoring tiles for BRAF-mutated and BRAFwild-type status for the best in-domain Wang+attMIL model deployed on the DACHS cohort. For better interpretability, six out-of-focus tiles are not shown in this panel. In (E)–(G), top tiles are the highest, top 5%, and top 10% scoring tiles in terms of the product of the tile’s attention and the tile’s classification score (left to right) for the patients with the highest overall classification score for the target mutation (top to bottom). High-resolution images can be found at Zenodo:https://doi.org/10.5281/zenodo.7454743. Correlation of prediction scores for MSI and BRAFstatus for the best image-only model can be found inFigure S6.
