Microscopy from Scientific Research

BRAF score with corresponding attention maps for a typical MSI- and BRAF-positive patient from the DACHS cohort. Scores were obtained with the best in-domain models trained on QUASAR (Wang-attMIL model). The displayed attention distribution is the normalized attention a=a-amin/amax-amin, where a is the attention score and amin and amax are the minimum and maximum scores on the WSI. This attention map highlights relevant tumor regions, irrespective of whether they were predicted to be MSI or MSS. The classification scores of the model show the MSI-ness and BRAF-ness for each tile. In both cases, the model correctly predicted MSI and BRAF status on the patient level.

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