Illustration from Scientific Research

The four DMPK family members (CRIK, DMPK, MRCK, and ROCK) are depicted bound to a hypothetical membrane. Specific membrane anchors are indicated where known. The coiled-coil domains are depicted at their maximum extensions based on experimental analysis of DMPK, MRCK1, and ROCK2 together with bioinformatic analysis of all four family members. A ruler indicates the distance that they are capable of spanning between the membrane and a hypothetical position in the actin cortex.

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