Heatmap from Scientific Research

Synaptic dissimilarity matrices based on the somatic distance (top left) and dendritic clustering (top right) of synapses, in the biophysical model, and the weight (bottom left) and subunit assignment (bottom right) of synapses in the cascade models trained to predict either vnoNa or vNa (bottom two rows, averaged across fits to different training datasets). The dendritic clustering-based morphological dissimilarity matrix was computed only for clustered synapses and orthogonalized with respect to the corresponding (top left) block of the somatic distance-based morphological dissimilarity matrix (see alsoSTAR Methods). Magnified top left blocks in the right column are shown to highlight characteristic block structure reflecting clustering.

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