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Experimental design. Cohorts of young (2 months old, n = 10), intermediate (6 months old, n = 4) and middle-aged (12-14 months old, n = 14)Fgd5CreERT2/+;Rosa26LSL-Tomato/+mice were fed with tamoxifen (TAM) for 16 weeks, followed by regular chow for 24 weeks (chase phase). The mice were monitored every 4 weeks for tdTomato labeling in peripheral blood (PB).
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