Protein Structure from Scientific Research

Heatmaps of surface occupation of RBD by early-pandemic, Beta, BA.1, and BA.2 antibody panels by iron heat colors (black > blue > red > orange > yellow > white hot) according to the relative level of antibody contact, calculated for each surface vertex as the number of antibodies within a 10 A radius. BA.1 mutations are shown by the spikes. Only the early-pandemic-all panels and the sub-variant substitutions discussed here are shown mapped onto BA.2. Early-pandemic, Beta, and BA.1 data are taken from Dejnirattisai et al.,4Nutalai et al.,13Liu et al.14 See alsoFigure S1.

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