Top: raster plot for a twinned network (red, pyramidal neurons; blue, interneurons), with weak internetwork (I-EandE-I) and strong intra-network (I-IandE-E) connections. Bottom: time course of field potential (f.p.; simulated for pyramidal neurons at 250 μm from the network, tissue conductance of 100 mS cm−1;STAR Methods) and [GABA]e, as indicated. Key model parameters: N = 200 (100 pyramidal cells and 100 interneurons),Gii= 0.216 mS cm−2,Gee= 0.003 mS cm−2; internetwork peak synaptic conductanceGei= 0.00012 mS cm−2andGie= 0.00064 mS cm−2,E-currents (Poisson series)gsi= 0.3 mS cm−2, tau = 3 ms,fs= 20 Hz;I-current (Poisson series)gse= 0.003 mS cm−2, decay constant tau = 3 ms,fs= 20 Hz,VGABA= −58 mV,Af= 2 × 10−7nS cm−2ms−1,Gpump= 0.003 ms−1. SeeFigures S3andS4for further exploration of the model parameter space.
