Box Plot from Scientific Research

Human version of the motifs bound by the stripe TFs confers a higher regulatory element potential to the linked enhancers than the chimpanzee version of the stripe TFs recognition sequence. Left: change in the CNN recall of human and chimpanzee versions of enhancers gained or lost in evolution. Right: change in CNN response of the linked enhancers induced by replacing the human stripe TF motifs to their chimpanzee version. The control group: enhancers linked with upregulated EAGs where sequences were mutated randomly (keeping the total number of mutations equal to the one observed in human-chimpanzee comparison;pWilcoxon test).

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