Quantification of cell fate changes and digital reconstruction of representative organoids cultured in lactate (n= 4, same plot as the lactate condition inFigure 2E), or in combination with JQ1 (100 nM, lactate + BETi,n= 3), or with 10058-F4 (500 nM, lactate + 10058-F4,n= 3). Details of the analyzed organoids are inTable S2. Pink, green, and gray represent differentiation (DIFF), dedifferentiation (DEDIFF), or no change (NC), respectively. White cells: undefined (pvalue DEDIFF: lactate vs. lactate+BETi 0.0209, lactate vs. lactate+10058F4 0.0525). Control values are shown inFigure 2E. Dunnett’s multiple comparisons test for (D) and (F)–(I).
