The RLU (luciferase) signal reading out from the tested S variant pseudoviruses. The green, gray, and red columns represent the WT, G502D, and D614G reference strain, respectively. The purple columns represent the N -glycan-related S variants (Y369N, A372S/T, L390S/T, G413N). The blue columns indicate the possible furin cleavage-related S variants (F374K, V382E, S383N, P384D, K386E, K386N, K386V, L390E, N440F, M900V, and T1117M). The brown columns represent the S variants (T430Q, Q498W, and N501Y) with comparable infectivity to WT. The orange columns indicate the S variants with improved infectivity (S205F, Y453F, Q493A, Q493M, Q498H, Q498Y, N501F, and N501T).
