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Oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) of glucose-deprived TPO3 upon D-glucose (12 mM) or L-lactate (24 mM) injection with or without pre-treatment of 10 μM UK-5099 (UK) (representative experiment,n= 4). The glucose-free medium was supplemented with glutamine, pyruvate, and B27. In (A)–(D), (G), and (I), control refers to 12 mM glucose, lactate refers to 23 mM lactate + 0.5 mM glucose, and pyruvate refers to 23 mM pyruvate + 0.5 mM glucose. In (B), (C), and (G)–(K), data are presented as mean ± SEM. (ns: non-significant). See alsoData S1andFigure S3.

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