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Quantification of cell fate changes in control (n= 7) and lactate (n= 4) TPO3 organoids (seeTable S2). Digital reconstruction of representative organoids depicting cell fate change. Pink, green, and gray represent differentiation (DIFF), dedifferentiation (DEDIFF), or no change (NC) in cell fate, respectively. White cells are undefined (mean, Mann-Whitney test,pvalue of control vs. lactate DIFF: 0.073, DEDIFF: 0.003, and NC: 0.65).
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