Chemical Structure from Scientific Research

Catalytic C-H arylation of 1r leading to carbo[6]helicene 2r. a Optimized reagents and conditions: 1r (0.1 mmol, 1.0 equiv.), Pd 2 dba 3 (5 mol%), ligand (20 mol%), Cs 2 CO 3 (0.5 equiv.), CPME (1 ml), 140 C, 17 h. CPME, cyclopentyl methyl ether; cat., catalyst. b , Effect of ligand structure and substitution pattern on the yield and enantioselectivity of the C-H arylation of 1r with the optimal ligands L 1 and L 2 selected in this study. The e.r. values were determined by HPLC on a chiral stationary phase.

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