LSEA results for ASD diagnosis, IQ/DQ and sleep disturbances (CSHQ total score). FDR-significant results (q < 0.05) are shown. The rows show lipid annotations. The bar lengths represent -log10[P value for the LSEA] multiplied by the test statistic sign. Asterisks represent annotations that were also significant by LWAS. Linoleic acid-containing lipid species map to fatty acid 18:2 and omega-6 features. Arachidonic acid-containing lipid species map to fatty acid 20:4 and omega-6 features. DHA-containing lipid species map to fatty acid 22:6 and omega-3 features. LC-PUFAs (including linoleic acid, arachidonic acid and DHA) correspond to lipids with both long fatty acid chains (18 carbons or more) and omega-3 or omega-6 features. At the feature hierarchical level, there were sometimes multiple annotations relating to a single feature (for example, feature-omega-6 as well as subclass-plasmalogen | feature-omega-6), so the values in b correspond to the most significant annotation. We have ensured that these match the LWAS hits (Supplementary Tables 11 – 13). AC-OH, hydroxylated acylcarnitine; LPE(P), alkenyllysophosphatidylethanolamine; PE(O), alkylphosphatidylethanolamine; SM, sphingomyelin.
