Direction of association and level of significance of pleiotropic SNPs displayed in a: in red when the risk allele for extensive PVS burden is positively associated with the trait, in blue when the PVS risk allele is negatively associated with the trait (unexpected direction), in dark red and dark blue for genome-wide significant associations and in light red and light blue for significant association after multiple-testing correction (P < 3.3 x 10 -5, two-sided, correcting for multiple testing (21 independent phenotypes, 3 PVS locations and 24 independent loci)). PP, pulse pressure; BMI, body mass index; LDL, LDL cholesterol.
