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Dosing and CSF sample collection for MAD part 1. CSF samples were obtained before the administration of study drug on days 1, 29, 57 and 85 for cohort A (10 mg MAPT Rx or placebo monthly), cohort B (30 mg MAPT Rx or placebo monthly) and cohort C (60 mg MAPT Rx or placebo monthly) and on days 1 and 85 for cohort D (115 mg MAPT Rx or placebo quarterly). The results of CSF samples obtained during screening and on day 1 (baseline) were averaged to serve as the baseline assessment, and the CSF samples on days 29, 57 and 85 served as 28 day, 56 day or 84 day post-dose trough samples. Two CSF samples were obtained in the post-treatment period, on either day 113 or day 141 for cohorts A and B and day 141 and day 197 for cohorts C and D.

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