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Different colors distinguish different SARS-CoV-2 lineages and some clades have been labeled to illustrate the level of detail shown. Left: MAPLE was applied to SARS-CoV-2 genome sequence data containing 500,000 samples to estimate their phylogeny. Centre: a subtree of 3,600 B.1.177 lineage samples (red inset, ~100x magnification of portion of left panel). Right: a subtree of 49 B.1.177 lineage samples (blue inset, ~100x magnification of portion of red inset). 2023, De Maio, N. et al. CCBY 4.0 .

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