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Schematic indicating which features make REs sensitive (blue) or buffered (orange) to SOX9 dosage. Dosage-sensitive effectors are REs and genes mediating changes in cellular behaviors as a result of quantitative changes to their activity or expression, and thus with high phenotypic impact (dashed rectangle), as compared to sensitive genes with low phenotypic impact (gene B) or phenotypically impactful genes that are buffered (gene D). LoF, loss of function.

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