Density Plot from Scientific Research

Genes expressed in mESCs were ranked based on the ChIPseq signal of the indicated marks in promoter regions (within 1 kb of the TSS). Shown are the composite nascent RNA transcription profiles for all genes, as well as the top 100, 500 and 1,000 genes with the highest abundance of the indicated mark. Within each group, the fraction of A-485-downregulated genes is indicated. Change in nascent transcription was determined by EU RNA-seq in mESCs treated without or with A-485 (1 h) 21 . The dotted lines indicate a twofold downregulation of nascent transcription after A-485 treatment.

DOI