Relative ChIPseq signal intensities of the indicated histone marks at the H3K27ac + (left) or H3K9ac + (right) peak regions. The H3K27ac and H3K9ac peak regions were further grouped into the indicated categories, as specified in Fig. 2e . Active promoters are defined as TSSproximal regions (+/-1 kb from the TSS) of actively transcribed (RNAseq, TPM >= 2) genes in K562 cells and whose promoters are marked with H3K4me3. Number of ChIPseq biological replicates: H3K4me3 (n = 2); H2BK20ac (n = 2); H3K9ac (n = 2); H3K27ac (n = 1). The box plots display the median, upper and lower quartiles; the whiskers show the 1.5x IQR. Twosided MannWhitney U test, adjusted for multiple comparisons using the BenjaminiHochberg method; * P < 0.05, ** P < 1 x 10 10 , *** P < 1 x 10 50 .
