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Combination of H2BNTac and other histone marks discriminate transcriptionally active and inactive PINTS regions. Transcriptionally active and inactive regions in K562 cells were defined based on RNA expression evidence in K562 and nonK562 cell lines 14 . PINTS regions were further classified as proximal or distal as defined by Yao et al. 14 ( Methods ). The discriminatory potential of different histone marks was analyzed by comparing ChIPseq signal enrichment within +/-500 bp of PINTS region centers. The true positive rate (TPR) and false positive rate (FPR), and AUPRC and AUROC are shown. The curves were generated under the different thresholds of peak enrichment or peak enrichment ratios.

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