Line Plot from Scientific Research

Open access visualization of Line Plot, Tumor Mutations, Whole Genome Sequencing, Sensitivity, Positive Predictive Value
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Sensitivity for detecting clonal tumor mutations from CODEC WGS (3x duplex depth; 18x coverage) and corresponding PPV. The data were analyzed by requiring either ≥1 or ≥2 duplexes bearing the same mutation. Standard Illumina NGS at x18 coverage paired with Mutect2 (ref. 34 ) achieved 98.6% sensitivity and 92.8% PPV. Theoretical numbers and projections (dashed) were calculated based on binomial models.

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