Line Plot from Scientific Research

Variants of the antibody C143, obtained from our language-model-guided affinity maturation campaign, demonstrate improved neutralization activity in a pseudovirus assay. For Beta pseudovirus, out of the three higher-affinity variants that we also screened for neutralization activity, the best improvement is the 32-fold improvement of VL G53V; for D614G pseudovirus, the best improvement is the 19-fold improvement of VL T33N-G53V (Supplementary Table 9 ). Also see Extended Data Fig. 2 . Points indicate the mean; error bars indicate the s.d.; n = 4 independent experiments.

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